According to leading Periodontists, BioGraft Granules and Blocks are excellent indigenously manufactured and moderately priced Bone Regenerative Materials for treatment of Periodontitis, a disease whereby tooth may have severely weakened because of loss of jaw bone. BioGraft Granules and Blocks, available in two varieties ie Synthetic Hydraoxyapatite and combination of Synthetic Hydroxyapatite and Beta Tri Calcimum Phosphate in micron size ranging from 250 to 3000, are both bio-compatible and bio-active materials and are used for generat ion of bone growth in areas affected by such disease. Stoichometry of these materials is very similar to that of natural bone. These patented materials are regularly being used by Periodontists and clinical results are extremely satisfactory. With increased thrust on retention of teeth and lot of work being done on improvement of smile, more and more people are availing services of Periodontists for treatment of Periodontitis.

Periodontists specializes in treatment of Periodontitis (peri = around, odont = tooth, -itis = inflammation) referring 20to a number of inflammatory diseases affecting the periodontium - that is, the tissues that surround and support the teeth. Periodontitis involves progressive loss of the alveolar bone (part of jaw bone which is housing the tooth root) around the teeth, and if left untreated, can lead to the loosening and subsequent loss of teeth. Different form of Periodontitis are caused by bacterial infections and important factors thereof include hypertension, mental retardation, blood disorders, smoking, poorly-controlled diabetes, pregnancy, menopause, puberty and inherited (genetic) susceptibility.

A diagnosis of periodontitis is established by inspecting the soft gum tissues around the teeth with a probe and radiographs by visual analysis, to determine the amount of bone loss around the teeth. Periodontitis is very common, and is widely regarded as the second most common disease worldwide, after dental decay. Its onset is very slow and hardly cause any symptoms or problems in the initial stages. By the time symptoms like loosening of teeth, spreading of teeth with appearance of spaces etc become visible, substantial portion of alveolar bone may have been lost.

1. Dental & Maxillofacial Trauma including fractures of mandible, maxilla, zygoma, TM joint injuries and dentoalveolar complex injuries.
2. Cysts and Tumors of face and jaws.
3. Cosmetic Surgical treatment of malaligament and maldevelopment of jaws, including dentofacial deformities, assymetry etc.
4. Reconstructive surgeries following trauma or cancer surgery of the dentofacial region.
5. Periodontists – loosening of teeth following loss of alveolar ridge bone, augmentation of Bone for fixation of Dental Implants.
6. Surgeries involving management of oro-facial region.

BioGraft Bone Regenerative materials presently available in two varieties (a) Synthetic Hydroxyapatite and (b) combination of Synthetic Hydroxyapatite and Beta-Tri Calcium Phosphate are both bio compatible and bio active and hydroxyapatite phase is the major constituent. These materials of Porus Crystaline structure provides obteoconductivity and resorbability. Hydroxyapatite has a stoichiometry similar to natural bone structure and provides an osteoconductive scaffold in the bone regenerative process.

BioGraft-HA and BioGraft-HT are both available=2 0in Granule size ranging from 250 to 3000 micron and preformed blocks i.e. square, rectangular, cylindrical shapes of different sizes. These patented Products manufactured under processes having both ISO 9001:2000 and CE 1023 Certifications are already being used by Oral and Maxillofacial Surgeons and quality and performance thereof have been found to be good on clinical and radiological examination at regular intervals and have showed explicit obteoblastic turnover

BioGraft Bone Regenerative materials are chemically derived and synthesized at high temperature and characterized for purity, chemical composition, particle size distribution, bio-compatibility etc. As per clinical, radiological and histo-orphological studies, they are suitable for filling traumatic and pathological bone defects.

Following are properties of BioGraft Bone Regenerative materials.

• Bio Compatible – Excellent bio compatibility and binds directly to bone.
• Non Immunogenic – Surrounded by Cellular infiltrate which is predominantly fibroblastic.
  • No Lysis of RBC
  • No Cytotoxic effect on surrounding cells.
  • No tissue necrosis
• Osteo Coductive – Bonding with Bone commences within three months, fastest of all Ceramic constituents.
  • Ca/P ratio is similar to that of human bone.
  • Crystalline structure and morphology similar to natural bone.

Indications of BioGraft Bone Regenerative materials for Orthopaedic applications are the following:

• Spinal Fusion
• Vertebral Fractures
• Bone Void filler
• Tibial Plateau Fracture
• Distal Radical Fractures
• Calcaneus Fractures

Method of application is quite simple inasmuch as BioGraft Granules and/or Blocks are generally wetted with patients blood or saline solution  and are placed directly on the application  area followed by sutures. Porous structure promotes colonization of Osteogenic cells from the patients bloods. For large cavities, bigger sizes of Granules/Pre-forms may be used together with patient’s own bone.

For further details, please refer to Brochure.

Indian Society Of Prosthodontics-Restorative- Periodontics (ISPRP)

Biograft - synthetic hydroxyapatite and beta tricalcium phosphate promising bio materials especially in the orthopaedic and dental fields By Dr G Banerjee, Retd Scientist of CGCRI and Director of IFGL Bio Ceramics Limite